If biotin is used concurrently with anticonvulsant products, the plasma BIOTIN WOLVIT® 5 mg Film Coated Tablets Vitamin levels concentration of biotin may be reduced as a result of elimination with urine. Valproic acid lowers the activity of biotinidase, which reduces mitochondrial activity in liver. The raw eggs contain the protein – avidin, which interacts with biotin, so it is necessary to avoid concomitant administration. Administration of a large quantity of raw eggs over 2-3 weeks can cause biotin deficiency. Pantothenic acid in high doses competes with biotin, therefore their concomitant administration should be avoided. Interference with clinical laboratory tests: Biotin may interfere with laboratory tests that are based on a biotin/streptavidin interaction, leading to either falsely decreased or falsely increased test results, depending on the assay. The risk of interference is higher in children and patients with renal impairment and increases with higher doses. When interpreting results of laboratory tests, possible biotin interference has to be taken into consideration, especially if a lack of coherence with the clinical presentation is observed (e.g. thyroid test results mimicking Graves’ disease in asymptomatic patients taking biotin or false negative troponin test results in patients with myocardial infarction taking biotin). Alternative tests not susceptible to biotin interference should be used, if available, in cases where interference is suspected. The laboratory personnel should be consulted when ordering laboratory tests in patients taking biotin.